Molecular formula: C24H30N2O7H2O
Advantame can be used as a table top sweetener and in certain bubblegums, flavored drinks, milk products, jams and confectionery among other things.
The FDA acceptable daily intake of advantame for humans is 32.8 mg per kg of bodyweight (mg/kg bw), while according to EFSA it is 5 mg per kg of bodyweight (mg/kg bw).
Estimated possible daily intakes from foods are well below these levels. NOAEL for humans is 500 mg/kg bw in EU. Ingested advantame can form phenylalanine, but normal use of advantame is not significant to those with phenylketonuria. It also has no adverse effects in type 2 diabetics. It is not considered to be carcinogenic or mutagenic.
The Center for Science in the Public Interest ranks advantame as safe and as generally recognized as safe.